Fe-Doped MoS₂ Nanozyme for Antibacterial Activity and Detoxification of Mustard Gas Simulant

The peroxidase-like catalytic activity of various nanozymes was extensively applied in various fields. In this study, we have demonstrated the preparation of Fe-doped MoS₂ (Fe@MoS₂) nanomaterials with enhanced peroxidase-like activity of MoS₂ in a co-catalytic pathway. In view of Fenton reaction, the peroxidase-like Fe@MoS₂ nanozyme prompted the decomposition of hydrogen peroxide (H₂O₂) to a reactive hydroxyl radical (·OH). The efficient decomposition of H₂O₂ in the presence of Fe@MoS₂ has been employed toward the antibacterial activity and detoxification of mustard gas simulant. The combined effect of Fe@MoS₂ and H₂O₂ showed remarkable antibacterial activity against the drug-resistant bacterial strain methicillin-resistant Staphylococcus aureus and Escherichia coli with the use of minimal concentration of H₂O₂. Fe@MoS₂ was further applied for the detoxification of the chemical warfare agent sulfur mustard simulant, 2-chloroethyl ethyl sulfide, by selective conversion to the nontoxic sulfoxide. This work demonstrates the development of a hybrid nanozyme and its environmental remediation from harmful chemicals to microbes.