Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

968
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
968
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

383
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
383
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

183
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
183
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

663
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
663
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

658
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
658
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution01:09

One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

452
The one-compartment open model is a simplified approach used in pharmacokinetics to understand the distribution and elimination of a drug administered through an intravenous bolus. This model assumes rapid drug dispersal throughout the body and elimination using a first-order process. Key pharmacokinetic parameters, such as the elimination rate constant (k), half-life (t1/2), and the apparent volume of distribution (Vd), can be estimated from this model. The elimination rate is calculated...
452

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-powered bio-chip for ultra-sensitive dual MiRNAs detection: A portable platform for cancer biomarker analysis.

International journal of biological macromolecules·2025
Same author

Self-powered chip based on exonuclease-driven amplification for portable cancer biomarker detection.

Analytica chimica acta·2025
Same author

Analysis of Mutations in <i>Pneumocystis jirovecii</i> Dihydropteroate Synthase and Dihydropteroate Reductase Genes Among Non-HIV Patients in China.

Infection and drug resistance·2024
Same author

Exosomal non-coding RNAs: Emerging insights into therapeutic potential and mechanisms in bone healing.

Journal of tissue engineering·2024
Same author

Differences in Performance and Conductivity Persistence of New Reduced Graphene Oxide Air Filter Materials before and after Eliminating Static Electricity.

Materials (Basel, Switzerland)·2023
Same author

Biomaterials combined with ADSCs for bone tissue engineering: current advances and applications.

Regenerative biomaterials·2023

Related Experiment Video

Updated: Aug 28, 2025

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

1.7K

3D printed oral solid dosage form: Modified release and improved solubility.

Ning Wang1, Huixin Shi1, Shude Yang2

  • 1Department of Plastic Surgery, The First Hospital of China Medical University, 110001 Shenyang, Liaoning Province, PR China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 19, 2022
PubMed
Summary

3D printing (additive manufacturing) offers customized drug dosage forms with improved solubility and release. This review explores formulation and structural design for enhanced 3D printed oral medications.

Keywords:
3D printingModified releaseOral solid dosage formPolymer blendsPoor water-soluble drugs

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.2K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.1K

Related Experiment Videos

Last Updated: Aug 28, 2025

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

1.7K
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.2K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.1K

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery

Background:

  • Oral solid dosage forms are the most prevalent drug delivery method.
  • 3D printing (additive manufacturing) enables on-demand, customized oral solid dosage forms.
  • Traditional tablet manufacturing faces limitations in personalization and precise drug release control.

Purpose of the Study:

  • To review formulation selection and structural design strategies for 3D printed oral solid dosage forms.
  • To identify methods for improving drug solubility and modifying drug release profiles using 3D printing.
  • To address the current limitations in scientific standardization for formulation selection in 3D printing.

Main Methods:

  • Review of existing literature on formulation and structural design in 3D printed oral dosage forms.
  • Analysis of how formulation composition and printing structures impact drug solubility and release.
  • Identification of challenges and opportunities in the scientific selection of materials and design.

Main Results:

  • 3D printing allows for rational formulation selection and clever structural design to enhance drug solubility and precisely control drug release.
  • Current limitations include restricted formulation choices and a lack of standardized, scientific approaches to selection.
  • The structural design possibilities for 3D printed dosage forms are still relatively underexplored.

Conclusions:

  • More scientific and extensive formulation selection is needed for 3D printed oral solid dosage forms.
  • Sophisticated structural design is crucial for achieving modified drug release and improved solubility.
  • Further research is required to standardize formulation selection and expand design possibilities in pharmaceutical additive manufacturing.