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The Evolution of Fluorescence-Guided Surgery.
Stan Van Keulen1, Marisa Hom2, Haley White2
1Department of Oral and Maxillofacial Surgery and Oral Pathology, Amsterdam UMC, Amsterdam, The Netherlands.
Molecular Imaging and Biology
|September 19, 2022
Summary
Fluorescence-guided surgery, using agents like 5-aminolevulinic acid, is revolutionizing oncologic procedures. Recent FDA approvals mark significant progress in actualizing fluorescence imaging for image-guided cancer surgery.
Area of Science:
- Medical Imaging
- Surgical Oncology
- Biomedical Optics
Background:
- Ongoing advancements in fluorescent agents and imaging systems.
- Recent FDA approvals of key fluorescent agents (5-aminolevulinic acid, hexaminolevulinate, pafolacianine).
Purpose of the Study:
- Review the historical development of fluorescence-guided surgery.
- Highlight milestones in the clinical translation of fluorescence imaging.
- Examine the future of targeted fluorescence imaging in oncology.
Main Methods:
- Literature review of fluorescence-guided surgery evolution.
- Analysis of key milestones and FDA approvals.
- Exploration of future trends in targeted fluorescence imaging.
Main Results:
- Significant progress in actualizing fluorescence for image-guided oncologic surgery.
- FDA approvals have accelerated clinical adoption of fluorescence agents.
- The field is rapidly evolving towards more targeted fluorescence imaging.
Conclusions:
- Fluorescence-guided surgery is a rapidly advancing field with proven clinical benefits.
- Targeted fluorescence imaging holds immense potential for improving oncologic surgical outcomes.
- Continued innovation in agents and systems will further enhance image-guided surgery.
