Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-Lipogenic Effects of Iridoid-Rich Lonicera caerulea Berry Extracts in a Cortisol-Stimulated Adipocyte Model.

Journal of food science·2026
Same author

Postbiotic Metabolites of Proanthocyanidins Reduce Adipogenesis In Vitro by Suppressing De Novo Lipogenesis.

Molecules (Basel, Switzerland)·2026
Same author

Nutritional Value of Brewer's Spent Grain and Consumer Acceptance of Its Value-Added Food Products.

Foods (Basel, Switzerland)·2025
Same author

Distinct interactions of proanthocyanidins of various degrees of polymerization with TLR4 receptor on the integrity of differentiating Caco-2 cell monolayers through tight junction protein expression.

Archives of biochemistry and biophysics·2025
Same author

Optimization of Ultrasound-Assisted Extraction of Glucosinolates from Upcycled Cauliflower Using Response Surface Methodology.

Molecules (Basel, Switzerland)·2025
Same author

Development of a Scalable Extraction Process for Anthocyanins of Haskap Berry (<i>Lonicera caerulea</i>).

Molecules (Basel, Switzerland)·2025

Related Experiment Video

Updated: Aug 28, 2025

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.1K

Anthocyanin Encapsulated Nanoparticles as a Pulmonary Delivery System.

Madumani Amararathna1, David W Hoskin2, H P Vasantha Rupasinghe1,2

  • 1Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS, Canada B2N 5E3.

Oxidative Medicine and Cellular Longevity
|September 20, 2022
PubMed
Summary

Haskap berry anthocyanins encapsulated in carboxymethyl chitosan (CMC) nanocarriers show potential for direct lung delivery. These nanocarriers protect anthocyanins, enhance their therapeutic efficacy, and reduce lung tissue damage.

More Related Videos

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.2K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.0K

Related Experiment Videos

Last Updated: Aug 28, 2025

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.1K
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.2K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.0K

Area of Science:

  • Pharmacology and Toxicology
  • Materials Science
  • Biotechnology

Background:

  • Anthocyanins possess therapeutic properties but degrade after ingestion, limiting efficacy.
  • Direct delivery systems can enhance anthocyanin stability, bioavailability, and therapeutic effects.

Purpose of the Study:

  • To develop a direct delivery system for anthocyanins into pulmonary tissues using encapsulated nanocarriers.
  • To evaluate the efficacy and safety of haskap berry anthocyanin-loaded carboxymethyl chitosan nanocarriers for lung delivery.

Main Methods:

  • Haskap berry anthocyanins (cyanidin-3-O-glucoside rich) were encapsulated in polyethylene glycol-poly(lactide-co-glycolide), maltodextrin, and carboxymethyl chitosan (CMC) nanocarriers.
  • Encapsulation efficiency, cytotoxicity, and cytoprotective effects were assessed in lung epithelial cells (BEAS-2B).
  • In vivo studies in mice involved intranasal administration of nanocarriers, followed by UPLC/ESI/Q-TOF-MS analysis of lung tissue for anthocyanin detection.

Main Results:

  • Carboxymethyl chitosan (CMC) exhibited significantly higher anthocyanin encapsulation efficiency compared to other polymers.
  • CMC nanocarriers were non-cytotoxic to lung epithelial cells.
  • Anthocyanin-loaded CMC nanoparticles reduced carcinogen-induced oxidative stress and DNA damage in lung cells.
  • Anthocyanins and their metabolites were detected in mouse lung tissue after intranasal administration of nanocarriers.

Conclusions:

  • Carboxymethyl chitosan is a promising non-cytotoxic material for encapsulating haskap berry anthocyanins for direct lung delivery.
  • Direct delivery of anthocyanins to lung tissues via nanocarriers enhances retention, modulates metabolism, and improves therapeutic potential.