Compass Fundus-Guided Perimetry in Geographic Atrophy

Area of Science:

• Ophthalmology
• Medical Devices
• Retinal Imaging

Background:

• Geographic atrophy (GA) is a leading cause of vision loss.
• Accurate correlation between visual function and anatomical changes in GA is crucial for monitoring disease progression.

Purpose of the Study:

• To evaluate the compass (CMP) device for fundus-guided perimetry (microperimetry).
• To correlate perimetric retinal sensitivity (PRS) with geographic atrophy (GA) features using CMP.

Main Methods:

• Retrospective study of 56 eyes from 43 GA patients using compass 10-2 perimetry.
• Image analysis involved correlating fundus photography, visual field scores, autofluorescence (AF), and infrared (IR) images using GIMP and ImageJ software.
• Statistical analysis included Pearson's correlation, t-tests, and Spearman correlation.

Main Results:

• The compass device demonstrated high accuracy (AUC-ROC score of 93.4%) in correlating visual field data with GA features.
• Significant correlations were found between grayscale scores (GSS) from AF/IR images and perimetric retinal sensitivity (PRS).
• Strong correlations were observed between visual field metrics (total/pattern deviation) and between GSS and black/white variables.

Conclusions:

• The compass device appears reliable, quick, and safe for studying GA.
• Fundus-guided perimetry with direct visualization of the visual field on fundus photography enables precise GA assessment and monitoring.