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Juvenile secretory carcinoma and juvenile papillomatosis: diagnosis and treatment
Insights
Pediatric breast cancer is rare. This case highlights juvenile secretory carcinoma with juvenile papillomatosis in a young girl, both lacking hormone receptors, necessitating mastectomy.
Area of Science:
- Oncology
- Pediatric Pathology
Background:
- Breast cancer in children is exceptionally rare, accounting for less than 1% of all breast lesions in this demographic.
- Early detection and accurate diagnosis are crucial for rare pediatric malignancies.
Observation:
- A case study of a young girl presenting with a left breast mass first detected at 4.5 years of age.
- Surgical excision at 6 years of age revealed juvenile secretory carcinoma with concurrent juvenile papillomatosis.
Findings:
- Both the juvenile secretory carcinoma and juvenile papillomatosis components were negative for estrogen and progesterone receptors.
- This receptor status contrasts with findings in nondiseased breast tissue, analyzed via a novel monoclonal antibody technique.
Implications:
- This case underscores the importance of thorough histopathological evaluation for rare pediatric breast lesions.
- Understanding the receptor status in such rare tumors may inform future treatment strategies, despite the current rarity of targeted therapies for pediatric breast cancer.
Abstract:
Carcinoma of the breast in the child is a rare pathologic entity, constitutes less than 1% of all breast lesions in this age group. The case of a girl with a left breast mass first noticed at 4.5 years of age is presented. An eccentric subareolar mass was excised at 6 years of age, sparing her breast bud. This biopsy contained juvenile secretory carcinoma, with additional pathologic changes characteristic of juvenile papillomatosis. Both the juvenile papillomatosis component as well as the juvenile secretory carcinoma component were devoid of estrogen and progesterone receptors in contrast to nondiseased breast tissue. The assay for these receptors was performed using a new antireceptor monoclonal antibody technique. Simple mastectomy was performed after completion excision demonstrated tumor at the pectoralis major fascia.