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Updated: Aug 28, 2025

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
Published on: May 24, 2016
[Gallbladder metastasis of a malignant melanoma]
Alexander Strick1, Hans Busch1, Klaus Friedhoff1
1Klinik für Allgemein- und Viszeralchirurgie, Helios Klinikum Bonn/Rhein-Sieg.
Anamnesis And Clinical Examination:
A 56-year-old male patient consulted our surgical department presenting repetitive pain in his right upper abdomen and already known cholecystolithiasis. There were no other findings in the clinical examination; fever or abnormalities concerning bowel movement or micturition were denied. Except from the extirpation of a melanoma and an appendectomy years ago there were no relevant previous illnesses.
Diagnosis:
An external CT-Scan of the abdomen revealed a cholecystolithiasis and an unclear thickening of the gallbladder wall near the infundibulum. Blood results showed no relevant pathologic excursion.
Therapy And Clinical Course:
After uncomplicated laparoscopic cholecystectomy the results of the histopathologic examination revealed a metastasis of the melanoma, which was diagnosed and excised years ago. Additional staging showed pulmonal metastasis and resection in palliative intention was performed.
Conclusion:
Gallbladder metastasis of any cancer entities are a rare event, but some studies suggest that the number of events is underestimated concerning the malignant melanoma.If there is a corresponding medical history, symptoms should quickly lead to determined diagnosis and, if in doubt, to cholecystectomy.
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