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Association of advanced paternal age with lung function at school age

Chun-Chun Gau1,2,3,4, Hsin-Ju Lee1, Hung-Yi Lu1

  • 1Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, 5 Fu-Hsin Street, Kweishan, Taoyuan, Taiwan.

Respiratory Research
|September 20, 2022
PubMed

Insights

Advanced paternal age is linked to reduced lung function in children, particularly those exposed to environmental tobacco smoke or not breastfed. This highlights a novel adverse effect of paternal age on respiratory health.

Area of Science:

  • Pediatric Respiratory Health
  • Reproductive Epidemiology
  • Childhood Lung Function

Background:

  • Epidemiological studies suggest advanced paternal age impacts offspring health.
  • The specific effects on children's respiratory health remain unclear.

Purpose of the Study:

  • To investigate the association between paternal age and lung function in children.
  • To examine the relationship between paternal age and fraction of exhaled nitric oxide (FeNO).

Main Methods:

  • Analysis of data from 1330 children (mean age 6.4 years) from the LIGHTS cohort.
  • Measurements included lung function and FeNO.
  • Covariate-adjusted regression analyses were applied.

Main Results:

  • Increased paternal age was associated with decreased FEV1/FVC ratio and FEF75.
  • These associations were significant among children with prenatal exposure to environmental tobacco smoke (ETS) or those not breastfed.
  • No association was found between paternal age and FeNO.

Conclusions:

  • Advanced paternal age is linked to reduced lung function in school-aged children.
  • Children exposed to ETS prenatally or not breastfed are more vulnerable.
  • Further research is needed to confirm these findings.
Abstract

Keywords:
BreastfeedingChildrenEnvironmental tobacco smokeLung functionPaternal age

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