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The Rate of Successful Cardiopulmonary Resuscitation in COVID-19 Patients: A Retrospective Cohort Study
Behrooz Banivaheb1, Parmida Shahbazi1, Nima Hemmati1
1Minimally Invasive Surgery Research Centre, Iran University of Medical Sciences, Tehran, Iran.
Insights
Critically ill COVID-19 patients undergoing cardiopulmonary resuscitation (CPR) have significantly lower survival rates compared to non-COVID-19 patients. Being a COVID-19 case, ICU admission, and older age are key risk factors for mortality after CPR.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Cardiopulmonary Resuscitation
Background:
- The COVID-19 pandemic presented unique challenges in managing critically ill patients.
- Understanding the efficacy of cardiopulmonary resuscitation (CPR) and associated mortality risks in COVID-19 patients is crucial for clinical decision-making.
Purpose of the Study:
- To determine the success rate of CPR in critically ill COVID-19 patients.
- To identify probable risk factors contributing to mortality in COVID-19 patients following CPR.
Main Methods:
- Historical cohort study involving 737 critically ill patients (341 COVID-19 cases) from February to April 2020.
- Data extracted from a national integrated electronic health record system.
- Statistical analysis using logistic and Cox regression models to assess CPR success rates and risk factors.
Main Results:
- COVID-19 patients exhibited a significantly higher mortality rate post-CPR (99.1% vs. 74%) compared to non-COVID-19 patients.
- Independent risk factors for mortality included being a COVID-19 case (OR: 29.0), Intensive Care Unit (ICU) admission (OR: 2.6), and increased age.
- The hazard ratio for COVID-19 patients was 1.8, indicating a higher risk of mortality.
Conclusions:
- Critically ill COVID-19 patients have a substantially lower chance of survival after CPR compared to their non-COVID-19 counterparts.
- Prompt identification and management of risk factors such as COVID-19 status, ICU admission, and advanced age are vital for improving outcomes.
Abstract:
Background: This study aims to provide information on the success rate of CPR in COVID-19 patients and some probable risk factors of mortality in these cases. Methods: In this historical cohort design, the CPR success rate probable risk factors of 737 critically ill patients during the COVID-19 pandemic in 17 hospitals in the catchment area of Iran University of Medical Sciences, Tehran, Iran, was evaluated between Feb and Apr 2020. Data were extracted from a database that is a part of a national integrated care electronic health record system and analyzed with logistic and Cox regression models. Results: COVID-19 cases were 341 (46.3%). The mean age in COVID-19 cases and non-COVID-19 patients were 70.0±14.6 and 63.0±19.3 years, respectively (P<0.001). The mortality was significantly higher in COVID-19 patients (99.1% vs. 74%, OR: 39.6, 95%CI: 12.4, 126.2). Cardiovascular diseases were the most frequent underlying disease (46.3% of COVID-19 cases and 35.1% of non-COVID-19 patients). Being a COVID-19 case (OR: 29.0, 95%CI: 8.9, 93.2), Intensive care unit admission (OR: 2.6, 95%CI: 1.5, 4.6) and age for each ten-year increase (OR: 1.2, 95%CI: 1.1, 1.4) were observed to be independent risk factors of mortality following CPR. The hazard ratio of being a COVID-19 patient was HR= 1.8 (95%CI: 1.5, 2.1). Conclusion: Critically ill COVID-19 patients who undergo CPR have a decreased chance of survival in comparison to non-COVID-19 patients.
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