PREVALENCE AND PREDICTORS OF FATIGUE IN PATIENTS WITH EPISODIC MIGRAINE

The aim: We studied prevalence, intensity and predictors of fatigue in patient with episodic migraine (EM).

Materials and methods: We enrolled in the study 85 patients with EM and 88 healthy subjects. Fatigue was identified according to Fatigue Severity Scale. We recorded socio-demographic factors: gender, age, marital status, formal education level, employment status, smoking. Anxiety and depression symptoms were assessed by Hospital Anxiety and Depression Scale, daytime sleepiness was measured by Epworth scale. The co-morbidities included history of low back pain during last year, arterial hypertension, diabetes mellitus and abdominal obesity. It was analyzed usage of non-steroidal anti-inflammatory drugs, combined analgesics, triptans for abortive migraine treatment.

Results: Fatigue prevalence in patients with EM was 41,2%, which was significantly higher than in healthy controls (11,4%). Fatigue intensity in episodic migraineurs was 5,7 (4,9-6,8) and did not differ significantly from fatigue intensity in healthy individuals - 4,9 (4,5-5,8). In multivariate logistic regression analysis independent predictors of fatigue were only migraine-related factors (number of migraine headache days per month, headache severity and migraine prodrome presence). There was weak direct correlation between the number of headache migraine days per month and fatigue intensity.

Conclusions: 1. Fatigue prevalence in patients with EM is significantly higher than in healthy controls. 2. In patients with EM fatigue has migraine-related predictors.