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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
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A Spotlight on Drug-Induced Vasculitis.
Kinanah Yaseen1, Alana Nevares2, Hiromichi Tamaki3
1Department of Rheumatic and Immunologic Diseases Cleveland Clinic, 9500 Euclid Avenue/A50, Cleveland, OH, 44195, USA. Yaseenk@ccf.org.
Current Rheumatology Reports
|September 21, 2022
Summary
Drug-induced vasculitis (DIV) is a rare condition caused by medications, affecting various blood vessels. Prompt recognition and drug withdrawal are key for managing this challenging diagnosis.
Area of Science:
- Rheumatology
- Immunology
- Pharmacology
Background:
- Drug-induced vasculitis (DIV) is an uncommon condition linked to various medications.
- It can affect blood vessels of any size, presenting diagnostic challenges.
- Distinguishing DIV from primary systemic vasculitis is crucial for timely intervention.
Purpose of the Study:
- To review the clinical presentation and management of drug-induced vasculitis.
- To emphasize the importance of early recognition and drug discontinuation.
Main Methods:
- Literature review of drug-induced vasculitis cases.
- Analysis of clinical phenotypes and treatment outcomes.
Main Results:
- DIV presents diversely, depending on affected vessel size, from joint pain to multi-organ involvement.
- Drug withdrawal is primary management; immunosuppressive therapy is often required.
- Early recognition by physicians is vital for improved patient outcomes.
Conclusions:
- Drug-induced vasculitis requires heightened clinical awareness for prompt diagnosis.
- Management involves discontinuing the causative agent and potentially immunosuppression.
- Further research may elucidate specific drug-vasculitis associations and treatment protocols.
Keywords:
CocaineDrug-induced ANCA-associated vasculitisDrug-induced vasculitis (DIV)Granulocyte colony-stimulating factor (G-CSF)HydralazineImmune checkpoint inhibitors (ICIs)MinocyclinePropylthiouracilTumor necrosis factor-α (TNF-α)More Related Videos
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