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Published on: December 13, 2018
Comprehensive elaboration of circular RNA in multiple myeloma
Chunsheng Zhu1, Aoxiang Guo2, Bao Sun3,4,5
1Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Abstract:
Circular RNAs (circRNAs), a novel category of endogenous non-coding RNAs, are usually well conserved across different species with a covalent closed-loop structure. Existing and emerging evidence confirms that circRNAs can function as regulators of alternative splicing, microRNA and RNA-binding protein sponges and translation, as well as gene transcription. In consideration of their multi-faceted functions, circRNAs are critically involved in hematological malignancies including multiple myeloma (MM). In particular, circRNAs have been found to play vital roles in tumor microenvironment and drug resistance, which may grant them potential roles as biomarkers for MM diagnosis and targeted therapy. In this review, we comprehensively elaborate the current state-of-the-art knowledge of circRNAs in MM, and then focus on their potential as biomarkers in diagnosis and therapy of MM.
Insights
Circular RNAs (circRNAs) are key regulators in multiple myeloma (MM). This review explores their roles in MM diagnosis and targeted therapy, highlighting their potential as biomarkers.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Circular RNAs (circRNAs) are endogenous non-coding RNAs with a unique closed-loop structure.
- circRNAs regulate gene expression through various mechanisms, including splicing, miRNA sponging, and translation.
- These molecules are increasingly recognized for their involvement in hematological malignancies like multiple myeloma (MM).
Purpose of the Study:
- To review the current understanding of circRNAs in multiple myeloma (MM).
- To explore the potential of circRNAs as diagnostic biomarkers for MM.
- To discuss the therapeutic implications of circRNAs in MM treatment.
Main Methods:
- Comprehensive literature review of studies on circRNAs and MM.
- Analysis of existing evidence on circRNA functions in MM pathogenesis.
- Evaluation of circRNAs' roles in the tumor microenvironment and drug resistance.
Main Results:
- circRNAs are implicated in the regulation of MM progression.
- circRNAs play significant roles in the MM tumor microenvironment.
- circRNAs are associated with drug resistance in MM patients.
Conclusions:
- circRNAs hold considerable promise as biomarkers for MM diagnosis.
- circRNAs offer potential targets for novel MM therapies.
- Further research into circRNAs could advance MM treatment strategies.
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