Biomimetic hydroxyapatite paste for molar-incisor hypomineralization: A randomized clinical trial

Area of Science:

• Dental Biomaterials
• Pediatric Dentistry
• Cariology

Background:

• Molar-incisor hypomineralization (MIH) affects enamel quality in permanent molars and incisors.
• MIH can lead to dental sensitivity, tooth wear, and aesthetic concerns.
• Effective treatments for MIH are crucial for improving oral health outcomes.

Purpose of the Study:

• To evaluate the desensitizing and remineralizing effects of a novel zinc-hydroxyapatite paste.
• To assess the impact of the paste on dental sensitivity, tooth wear, and periodontal health in MIH-affected sites.
• To compare the outcomes in a test group using the paste with a control group.

Main Methods:

• A randomized clinical trial involving 25 patients with MIH.
• Application of zinc-hydroxyapatite paste to MIH teeth in one quadrant (test group).
• Assessment of Plaque Control Record (PCR), Bleeding Index (BI), MIH Treatment Need Index (MIH-TNI), and Schiff Air Index (SAI) over time.

Main Results:

• No significant differences in plaque or bleeding indices between groups.
• Significant improvements in MIH Treatment Need Index observed in the test group after 9 months.
• Significant reduction in Schiff Air Index (dental sensitivity) in the test group at 1 and 3 months.

Conclusions:

• Biomimetic zinc-hydroxyapatite paste demonstrates a desensitizing effect in treating MIH.
• The paste shows potential for managing dental sensitivity associated with MIH.
• Further research may explore long-term remineralizing effects and broader applications.