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Candida glabrata Empyema Thoracis-A Post-COVID-19 Complication

Neeraja Swaminathan1, Katherine Anderson2, Joshua D Nosanchuk1

  • 1Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA.

Journal of Fungi (Basel, Switzerland)
|September 22, 2022
PubMed

Insights

COVID-19 survivors face increased fungal infections. This case highlights Candida glabrata fungal empyema thoracis, a rare complication requiring prompt diagnosis and specific antifungal strategies.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Mycology

Background:

  • The COVID-19 pandemic has seen a rise in invasive fungal infections.
  • Fungal empyema thoracis (FET) is a rare but serious complication of invasive fungal disease (IFD).
  • Effective management of non-bloodstream Candida infections remains challenging.

Observation:

  • A patient with post-COVID-19 pneumonia developed a polymicrobial empyema.
  • Candida glabrata was identified as a causative agent in the empyema.
  • This represents a novel manifestation of COVID-19-associated opportunistic fungal infection.

Findings:

  • Candida empyemas are an emerging complication of COVID-19.
  • This case underscores the need for high clinical suspicion for fungal infections in post-COVID-19 patients.
  • The first reported instance of Candida glabrata empyema thoracis post-COVID-19.

Implications:

  • Early detection and management of Candida empyema are crucial for improving patient outcomes.
  • Antifungal therapy for empyemas may need to differ from bloodstream infections due to pharmacokinetic challenges.
  • Further research is needed to optimize treatment for non-bloodstream Candida infections in the pleural space.
Keywords:
COVID-19Candida empyemaCandida glabrata

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