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Updated: Aug 28, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis and Chemosensory Properties of New Cyanosubstituted 2,2'-Bipyridine Derivatives
Mikhail Yu Ievlev1, Nikita S Mayorov2, Ivan N Bardasov2
1Ulyanov Chuvash State Univeristy, Moskovsky pr. 15, Cheboksary, Russia. hiliam@bk.ru.
Abstract:
A series of novel 6-oxo-1,6-dihydro-[2,2'-bipyridine]-5-carbonitriles has been synthesized and characterized. Their photophysical properties in DMSO solution and aqueous medium as well as fluorescence response to the presence of metal ions have been investigated. The obtained 4-(4-methoxyphenyl)-6-oxo-1,6-dihydro-[2,2'-bipyridine]-5-carbonitrile has been shown as a selective fluorescent "turn-ON" probe for Cd2+ ions with LoD 0.359 µM, 1:1 metal-ligand ratio and binding constant of 5.2 × 104 M-1.
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