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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Postbiotics and Kidney Disease.

Chiara Favero1, Laura Giordano2, Silvia Maria Mihaila2

  • 1Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, 28049 Madrid, Spain.

Toxins
|September 22, 2022
PubMed
Summary
This summary is machine-generated.

Emerging postbiotics, preparations of inanimate microbial components, show promise for treating kidney diseases. Research is advancing to translate these novel interventions from preclinical studies to clinical applications for better kidney disease management.

Keywords:
GABA-saltOxalobacter formigeneschronic kidney diseasehyperoxaluriapostbioticsprebioticsprobiotics

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Area of Science:

  • Microbiology
  • Nephrology
  • Gastroenterology

Background:

  • Chronic kidney disease (CKD) is a growing global health concern with limited treatment options.
  • The holobiont concept, encompassing host-microbe interactions, offers new insights into kidney disease.
  • Postbiotics, defined by ISAPP as inanimate microbial preparations conferring health benefits, are a novel therapeutic avenue.

Purpose of the Study:

  • To review the revised concept of postbiotics.
  • To explore potential clinical applications and research of postbiotics in kidney disease.
  • To provide a roadmap for advancing postbiotic research in nephrology.

Main Methods:

  • Review of updated postbiotic definitions by ISAPP.
  • Discussion of preclinical data for various postbiotic formulations.
  • Analysis of specific examples: GABA-salt, sonicated *Lactobacillus paracasei*, lacto-GABA-salt, and *O. formigenes* lysates.

Main Results:

  • Several postbiotic formulations demonstrate potential in preclinical models of kidney injury and related conditions like hypertension and hyperoxaluria.
  • The revised definition of postbiotics clarifies their composition and distinguishes them from purified metabolites.
  • Preclinical studies highlight specific applications for diet-induced and acute kidney injury, and hyperoxaluria.

Conclusions:

  • Postbiotics represent a promising area for novel therapeutic strategies in kidney disease.
  • Further research and clinical translation are needed to realize the full potential of postbiotics in nephrology.
  • A clear roadmap is essential to guide future postbiotic research and development for kidney disease treatment.