Related Experiment Video
Updated: Aug 28, 2025
10:27
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
1.6K
Role of circRNA in E3 Modification under Human Disease
Zishuo Chen1, Minkai Song2, Ting Wang1
1Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou 510515, China.
Biomolecules
|September 23, 2022
Summary
Circular RNAs (circRNAs) regulate ubiquitination, impacting disease development. Understanding this circRNA-mediated ubiquitination offers new diagnostic and prognostic insights for various conditions.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Circular RNAs (circRNAs) are non-coding RNAs implicated in disease regulation.
- Ubiquitination, a modification of ubiquitin protein, generates diverse cellular signals involved in disease pathogenesis.
- Dysregulation of ubiquitination pathways is linked to various pathologies.
Purpose of the Study:
- To review the characteristics of circRNAs and ubiquitination.
- To summarize the mechanisms by which circRNAs regulate ubiquitination.
- To explore the role of circRNA-mediated ubiquitination in disease.
Main Methods:
- Literature review of circRNA and ubiquitination studies.
- Analysis of molecular mechanisms linking circRNAs to ubiquitination pathways.
- Compilation of evidence for circRNA-mediated ubiquitination in diseases like tumors, neurological disorders, and inflammation.
Main Results:
- CircRNAs possess unique characteristics influencing cellular processes.
- CircRNA-mediated ubiquitination is a significant regulatory mechanism in disease.
- Specific examples of circRNA-ubiquitin interactions in various pathologies are discussed.
Conclusions:
- CircRNA-mediated ubiquitination is a critical factor in disease progression.
- This regulatory axis presents potential for novel diagnostic and prognostic biomarkers.
- Further research into circRNA-ubiquitination interactions may advance therapeutic strategies.
Related Concept Videos
02:23RNA Editing
9.1K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.1K
02:39lncRNA - Long Non-coding RNAs
8.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.8K
01:22MicroRNAs
21.5K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.5K
01:46Epigenetic Regulation
31.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.3K
02:41Chromatin Structure Regulates pre-mRNA Processing
7.1K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
The chromatin structure, especially...
7.1K
02:15Experimental RNAi
6.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K