[Modification of radiation changes in the hemato-encephalic barrier using exogenous hypoxia]

The authors conducted an experimental study of a radio-modifying effect of exogenous hypoxia on the structures of the blood-brain barrier in rats early after irradiation of the head at a dose of 10 Gy. Histochemical and histological methods were used to assess the status of the endothelium, basal membrane, tissue basophils and astrocytic junction. They indicated change of these structures in irradiation and action of GGS-8 gaseous mixture. Exogenous hypoxia was shown to promote the normalization of transport through the capillary wall as a result of the prevention of injury of the structure and metabolic processes in endothelial cells and basal membrane. The astrocytic junction and, to a certain degree, tissue basophils exhibited synergy in the action of the studied factors.