Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diagonal Z-lines: an unexplained electron microscopic finding.

H Isaacs, T Whistler

    Muscle & Nerve
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A SYNDROME OF CONTINUOUS MUSCLE-FIBRE ACTIVITY.

    Journal of neurology, neurosurgery, and psychiatry·2011
    Same author

    Fetal and neonatal cardiac tumors.

    Pediatric cardiology·2004
    Same author

    Pyogenic granuloma presenting as a congenital epulis.

    Archives of pediatrics & adolescent medicine·2000
    Same author

    Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture.

    Anesthesiology·1998
    Same author

    Evaluation of an 'in-house' diagnostic PCR for detection of various HIV-1 subtypes.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1998
    Same author

    Sequence analysis of the nucleocapsid gene of measles virus isolates from South Africa identifies a new genotype.

    The Journal of general virology·1997
    Same journal

    Fat-Fraction Quantification Using Three-Point Dixon Technique in Duchenne Muscular Dystrophy and Its Correlation With Clinical Progression and Genotypic Characteristics: A Single Centre One-Year Prospective Study.

    Muscle & nerve·2026
    Same journal

    Characterizing Combined Central and Peripheral Demyelination-Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis.

    Muscle & nerve·2026
    Same journal

    Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications.

    Muscle & nerve·2026
    Same journal

    Reply to "Sural/Radial Amplitude Ratio in Non-Length-Dependent Neuropathy (NLDN): A Call for More Standardized Methodology and Further Evaluation of Distal NLDN".

    Muscle & nerve·2026
    Same journal

    Late-Onset Myasthenia Gravis: An Increasingly Frequent Clinical Entity With Distinctive Challenges.

    Muscle & nerve·2026
    Same journal

    Clinical Characteristics and Treatment Management of Seronegative Myasthenia Gravis: A Systematic Review of the Literature.

    Muscle & nerve·2026
    See all related articles

    Muscle biopsies from a myasthenia gravis patient revealed unusual diagonal Z-lines within the I band of muscle fibers. The significance of this rare electron microscopic finding in myasthenia gravis remains unknown.

    Area of Science:

    • Neuromuscular Disorders
    • Muscle Histopathology
    • Electron Microscopy

    Background:

    • Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by fluctuating muscle weakness.
    • Muscle biopsies are sometimes performed to investigate the underlying pathology of neuromuscular conditions.

    Observation:

    • A patient diagnosed with myasthenia gravis underwent muscle biopsies of the deltoid and pectoralis muscles.
    • Electron microscopy was utilized to examine the ultrastructure of the muscle tissue.

    Findings:

    • The muscle biopsies revealed scattered Z-lines with an unusual diagonal orientation across the I band.
    • This specific Z-line anomaly has not been previously reported in the context of myasthenia gravis.

    Implications:

    Related Experiment Videos

    • The observed Z-line orientation represents a potentially novel ultrastructural finding in muscle.
    • Further research is needed to determine the significance and potential causal relationship of this finding to myasthenia gravis.