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Rodent Models of Post-Stroke Dementia
Hahn Young Kim1, Dong Bin Back1, Bo-Ryoung Choi1
1Department of Neurology, Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 05030, Korea.
International Journal of Molecular Sciences
|September 23, 2022
Summary
This review evaluates rodent models for post-stroke dementia (PSD), a common complication. Diverse models simulating various clinical conditions offer platforms for future PSD research.
Area of Science:
- Neuroscience
- Pathology
- Animal Models
Background:
- Post-stroke cognitive impairment and dementia (PSD) are frequent complications in stroke survivors.
- Vascular risk factors and underlying pathologies contribute to PSD development.
- A single animal model cannot encompass the diverse clinical conditions of PSD.
Purpose of the Study:
- To evaluate diverse rodent models simulating various clinical conditions of PSD.
- To classify and discuss the characteristics and clinical significance of these models.
Main Methods:
- Literature review of rodent models for PSD.
- Classification of models into surgical technique, special structure, and comorbid condition categories.
Main Results:
- Rodent models for PSD are heterogeneous and can be categorized based on methodology.
- Detailed discussion of individual model characteristics and their clinical relevance.
Conclusions:
- Diverse rodent models mimicking PSD pathomechanisms are valuable.
- These models provide effective platforms for future PSD research and pathophysiology studies.
Keywords:
amyloid depositschronic cerebral hypoperfusionintracerebral hemorrhageischemic strokepost-stroke dementiarodent modelsubarachnoid hemorrhage
