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The Use of Yeast in Biosensing
1School of Science, RMIT University, Bundoora, VIC 3083, Australia.
Microorganisms
|September 23, 2022
Summary
Yeast, a simple eukaryote, is a valuable biosensor for disease research and drug discovery due to its conserved genetics and unique features. This review explores yeast
Area of Science:
- Microbiology
- Biotechnology
- Eukaryotic Cell Biology
Background:
- Yeast serves as a simple unicellular eukaryote model organism.
- It shares fundamental biological processes with higher eukaryotes, including humans.
- Yeast is safe, easy to culture, and genetically tractable.
Purpose of the Study:
- To review the utilization of yeast as a biosensor.
- To highlight yeast's responses to various stimuli.
- To showcase yeast's role in disease pathogenesis and drug discovery.
Main Methods:
- Literature review of yeast-based biosensing applications.
- Analysis of yeast's genetic and cellular characteristics relevant to biosensing.
- Compilation of studies reporting yeast responses to diverse environmental and biological stimuli.
Main Results:
- Yeast's conserved genetics and amenability to genome modification facilitate its use in biosensing.
- Its ability to tolerate mitochondrial defects offers flexibility in designing whole-cell biosensing systems.
- Yeast has been successfully employed to detect a wide range of substances and conditions.
Conclusions:
- Yeast is a versatile and powerful tool for developing whole-cell biosensing systems.
- Its fundamental biological relevance makes it ideal for disease modeling and drug discovery.
- Further exploration of yeast's capabilities will enhance its application in biotechnology and medicine.
