Colorectal carcinoma and cholecystectomy

In a group of 11,153 autopsied subjects a higher number of cholecystectomies was found in both sexes in individuals with large intestine tumors as compared with the rest of the autopsied persons without tumors (p less than 0.001). The results confirmed the hypothesis that cholecystectomy is a supporting factor in the process of carcinogenesis of the large intestine. We presume, in accordance to other studies, that the influence of cholecystectomy itself is not strong. For a development of a carcinoma, other carcinogenic factors must start or continue their effects. These factors are decisive for the genesis of a tumor.