Biopolymeric Prodrug Systems as Potential Antineoplastic Therapy

Area of Science:

• Biomedical Engineering
• Materials Science
• Oncology

Background:

• Cancer poses significant public health and economic challenges.
• Conventional chemotherapy has limitations, driving the need for novel therapeutic strategies.
• Biopolymer prodrug systems offer improved drug pharmacokinetics, pharmacodynamics, and reduced toxicity.

Purpose of the Study:

• To review the latest research on polymer-drug conjugates utilizing natural polymers for cancer therapy.
• To highlight the potential of natural biopolymers in developing advanced cancer treatment modalities.

Main Methods:

• Conjugation of antitumor molecules with natural polymers.
• Development of polymer-drug and polymer-enzyme conjugates for targeted drug delivery.
• Focus on biocompatible and biodegradable natural polymers.

Main Results:

• Natural polymers such as chitosan, hyaluronic acid, dextran, pullulan, silk fibroin, heparin, and Auricularia auricula polysaccharides are effective in polymer-drug conjugates.
• These systems demonstrate potential for targeted tumor cell delivery and drug release.
• The use of natural polymers enhances biocompatibility and biodegradability of drug delivery systems.

Conclusions:

• Natural polymer-based biopolymer prodrug systems represent a promising advancement in cancer therapy.
• These systems offer a viable alternative to conventional chemotherapy with improved efficacy and safety profiles.
• Further research into natural polymer conjugates is crucial for developing next-generation cancer treatments.