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Related Experiment Videos

Craniosynostosis and hydrocephalus.

M Golabi, M S Edwards, D K Ousterhout

    Neurosurgery
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    This study reviewed 250 pediatric craniosynostosis cases, identifying 10 with hydrocephalus. Surgical shunting effectively managed hydrocephalus in all affected children, with various craniosynostosis syndromes noted.

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    Area of Science:

    • Pediatric Neurosurgery
    • Craniofacial Surgery
    • Pediatric Neurology

    Background:

    • Craniosynostosis, the premature fusion of skull sutures, affects approximately 1 in 2,500 live births.
    • Hydrocephalus, an abnormal buildup of fluid in the brain's ventricles, can occur secondary to various neurological conditions.
    • The association between craniosynostosis and hydrocephalus requires further investigation to understand underlying mechanisms and optimal management.

    Purpose of the Study:

    • To determine the incidence of hydrocephalus in a cohort of pediatric patients diagnosed with craniosynostosis.
    • To identify specific craniosynostosis syndromes associated with hydrocephalus.
    • To report on the management and outcomes of hydrocephalus in this patient population.

    Main Methods:

    Related Experiment Videos

  • Retrospective chart review of 250 pediatric patients with craniosynostosis.
  • Identification and classification of craniosynostosis syndromes (e.g., Pfeiffer, Crouzon, Kleeblattschädel).
  • Documentation of hydrocephalus diagnosis and management, including surgical intervention.

    • Main Results:

    • Ten out of 250 (4%) pediatric craniosynostosis cases presented with hydrocephalus.
    • Associated syndromes included Pfeiffer syndrome (4 cases), Crouzon syndrome (3 cases), Kleeblattschädel with multiple anomalies (2 cases), and isolated sagittal synostosis (1 case).
    • Hydrocephalus was successfully managed in all 10 patients via shunting procedures.

    Conclusions:

    • Hydrocephalus is a notable comorbidity in pediatric craniosynostosis, occurring in approximately 4% of cases.
    • The management of hydrocephalus in these patients, primarily through shunting, is effective.
    • Further research into the pathophysiology linking craniosynostosis and hydrocephalus is warranted.