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Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans.
1Section AIDS and Newly Emerging Pathogens, Department of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany.
Viruses
|September 23, 2022
Summary
Global smallpox eradication is complete, but Monkeypox virus (MPXV) is now spreading worldwide. Limited immunity exists, primarily in those vaccinated against smallpox, necessitating a review of MPXV knowledge and control strategies.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Smallpox was eradicated globally in the late 1970s through vaccination programs.
- Monkeypox virus (MPXV), a close relative of variola virus, is experiencing a global spread.
- Protection against poxviruses is waning, with only older, smallpox-vaccinated populations retaining significant immunity.
Purpose of the Study:
- To summarize current knowledge on Monkeypox virus (MPXV).
- To describe the disease caused by MPXV infections.
- To outline strategies for limiting the spread of MPXV.
Main Methods:
- Literature review of existing research on MPXV.
- Analysis of epidemiological data on MPXV outbreaks.
- Synthesis of information on viral characteristics and disease presentation.
Main Results:
- MPXV is a significant public health concern due to its increasing global prevalence.
- Cross-protection from smallpox vaccination is limited and primarily found in older demographics.
- Understanding MPXV transmission and pathogenesis is crucial for effective control.
Conclusions:
- MPXV poses a growing global health threat requiring updated surveillance and response.
- Further research into MPXV is needed to develop targeted interventions.
- Public health strategies must address the limited existing immunity and potential for widespread transmission.
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