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Identification of Key Genes and Pathways Associated with Oxidative Stress in Periodontitis
Zheng Zhang1,2,3, Youli Zheng4, Xiaowei Bian4
1Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300000, China.
Oxidative Medicine and Cellular Longevity
|September 23, 2022
Summary
Six key oxidative stress-related genes (OS-genes) were identified as significant risk factors for periodontitis. These genes are linked to crucial cellular processes and signaling pathways involved in the disease progression.
Area of Science:
- Genomics
- Molecular Biology
- Periodontology
Background:
- Periodontitis is a prevalent inflammatory disease with complex underlying molecular mechanisms.
- Oxidative stress plays a significant role in the pathogenesis of periodontitis.
Purpose of the Study:
- To identify oxidative stress-related differentially expressed genes (OS-DEGs) in periodontitis.
- To screen key OS-genes and construct a risk score model for periodontitis.
- To elucidate the functional and pathway enrichment of identified key OS-genes.
Main Methods:
- Utilized GEO database for periodontitis microarrays and GeneCards for OS-genes.
- Applied Pearson correlation and protein-protein interaction analyses to identify key OS-genes.
- Performed gene set enrichment, functional enrichment, and pathway analyses.
Main Results:
- Identified 74 OS-DEGs, with 65 upregulated and 9 downregulated.
- Screened six key OS-genes (CXCR4, SELL, FCGR3B, FCGR2B, PECAM1, ITGAL) significantly associated with periodontitis risk.
- Functional analysis linked these genes to leukocyte adhesion, phagocytosis, and cellular extravasation.
Conclusions:
- Six key OS-genes were identified as risk factors for periodontitis.
- Multiple signaling pathways, including leukocyte transendothelial migration and osteoclast differentiation, are implicated in oxidative stress damage in periodontitis.
- Further experimental validation is required to confirm these findings.
