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Reference values for diaphragm electrical activity (Edi) in newborn infants.
Varappriyangga Gurumahan1, Sriganesh Thavalingam1, Tim Schindler1,2
1School of Women's and Children's Health, University of New South Wales, Sydney, Australia.
BMC Pediatrics
|September 23, 2022
Summary
Reference values for the electrical activity of the diaphragm (Edi) were established in neonates. These Edi values aid in monitoring and utilizing diaphragm-triggered respiratory support for infants.
Area of Science:
- Neonatal physiology
- Respiratory support
- Diaphragm electrical activity
Background:
- Neurally adjusted ventilatory assist (NAVA) uses diaphragm electrical activity (Edi) for synchronized inspiratory support.
- Limited data exists on Edi reference values in neonates.
- Establishing these values is crucial for optimizing respiratory support.
Purpose of the Study:
- To establish reference Edi values for both preterm and term neonates.
- To provide a baseline for Edi monitoring in infants not receiving respiratory support.
Main Methods:
- Prospective observational study of spontaneously breathing neonates.
- Edi waveform monitored using a naso/orogastric tube with embedded electrodes.
- Continuous Edi recording for 4 hours without altering clinical care.
Main Results:
- Twenty-four infants (16 preterm, 8 term) were studied.
- Mean Edi minimum: 3.02 ± 0.94 μV; Mean Edi peak: 10.13 ± 3.50 μV.
- Preterm infants: Mean Edi minimum 3.05 ± 0.91 μV, Mean Edi peak 9.36 ± 2.13 μV.
- Term infants: Mean Edi minimum 2.97 ± 1.05 μV, Mean Edi peak 11.66 ± 5.14 μV.
Conclusions:
- Reference Edi values were successfully established for preterm and term neonates.
- These values serve as a guide for monitoring breathing support.
- Facilitates the use of diaphragm-triggered respiratory support in neonates.
