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The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each indication due to...
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Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide (Glucotrol),...
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Updated: Jul 10, 2026

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults
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Published on: July 16, 2016

Sugar and sugar substitutes. Comparisons and indications.

R B Alfin-Slater, F X Pi-Sunyer

    Postgraduate Medicine
    |August 1, 1987
    PubMed
    Summary

    Sugar substitutes like aspartame and saccharin offer a safe, low-calorie option for most people. However, specific groups, including pregnant women and those with phenylketonuria, should avoid certain sweeteners.

    Area of Science:

    • Nutrition Science
    • Food Chemistry

    Background:

    • Widespread public concern exists regarding sugar and artificial sweetener consumption.
    • Physicians require guidance to address patient inquiries on sugar substitutes effectively.

    Purpose of the Study:

    • To clarify the safety and appropriate use of common sugar substitutes.
    • To identify specific population groups that should avoid certain sweeteners.

    Main Methods:

    • Literature review on the safety profiles of aspartame and saccharin.
    • Analysis of dietary guidelines and recommendations for specific populations.

    Main Results:

    • Aspartame and saccharin are safe for the general population in a balanced diet, offering reduced calories and cariogenic potential.

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  • Pregnant women and young children should avoid saccharin.
  • Individuals with phenylketonuria must avoid aspartame.

    • Conclusions:

    • Sugar substitutes can aid dietary compliance for overweight and diabetic individuals.
    • Informed use of aspartame and saccharin supports healthier eating habits for the general population.