Two-step recognition of HIV-1 DNA in the cytosol
Nicholas Dopkins1, Douglas F Nixon1
1Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.
Trends in Microbiology
|September 24, 2022
Abstract:
Retroviral DNA induces the production of interferons. A new study by Yoh et al. showed that the host factor 'PQBP1' primes immune-recognition of retroviral DNA by recruiting the cytosolic DNA scavenger 'cGAS' to the HIV-1 capsid. Their findings support the importance of innate immune sensing in HIV-1 infection.


