Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Composition of Blood Plasma

Composition of Blood Plasma

Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Single-nucleus multiomics unveils malignant cellular states, regulatory architectures and microenvironmental reorganization across the G-CIMP epigenomic transition in IDH-mutant glioma.

bioRxiv : the preprint server for biology·2026

Same author

New biomarkers for the detection of fetal death derived from large-scale proteomic analysis of maternal plasma.

American journal of obstetrics and gynecology·2026

Same author

A comparison of differential DNA methylation analysis methods for continuous outcomes: implications for epigenetic studies.

Epigenomics·2026

Same author

A subclinical cytokine storm is present before the clinical diagnosis of amniotic fluid embolism: implications for the prediction and prevention of maternal death.

American journal of obstetrics and gynecology·2026

Same author

Erratum: Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics.

iScience·2026

Same author

Benchmarking large language models for predictive modeling in biomedical research with a focus on reproductive health.

Cell reports. Medicine·2026

Same journal

Identification of Age-Associated Circulating Proteins and Lipids in 3800 Comorbidity-Enriched Older Adults from Japan-Based Cohorts Using Olink Assays and MRM Mass Spectrometry.

Journal of proteome research·2026

Same journal

Molecular Solution to the Paradox of Ancient Brain Preservation.

Journal of proteome research·2026

Same journal

From Method-Defined Signals to Reference Measurement Procedures: Two Decades of Mass Spectrometry-Based ProGRP Quantification.

Journal of proteome research·2026

Same journal

Proteomic Profiling of Extracellular Vesicle-Enriched Plasma Using Mag-Net for Biomarker Discovery in Pancreatic Ductal Adenocarcinoma.

Journal of proteome research·2026

Same journal

Computationally Efficient Bayesian Estimation of Graphical Networks for Omics Data.

Journal of proteome research·2026

Same journal

Hierarchy of MS-Based Evidence.

Journal of proteome research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 27, 2025

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Human Plasma Proteome During Normal Pregnancy.

Adi L Tarca^1,2,3, Roberto Romero^1,4,5,6,7, Gaurav Bhatti^1,2

¹Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and, Detroit, Michigan48201, United States.

Journal of Proteome Research

|September 26, 2022

Summary

This summary is machine-generated.

This study profiles the human plasma proteome during pregnancy, revealing dynamic changes linked to gestational age and placental development. These findings offer a new non-invasive method for monitoring pregnancy health and predicting obstetrical outcomes.

Keywords:

aptamer biomarker machine learning proteomic standards single-cell RNA signature

More Related Videos

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

Related Experiment Videos

Last Updated: Aug 27, 2025

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

Area of Science:

Proteomics
Maternal-Fetal Medicine
Biochemistry

Background:

The human plasma proteome remains underexplored for health and disease monitoring.
Pregnancy involves complex physiological changes impacting maternal and fetal health.

Purpose of the Study:

To profile the plasma proteome in normal pregnancies using an aptamer-based platform.
To identify proteomic changes associated with gestational age and placental development.
To assess the potential of plasma proteomic data for predicting pregnancy outcomes.

Main Methods:

Aptamer-based proteomic profiling of 7288 proteins in 528 plasma samples from 91 pregnancies.
Analysis of protein abundance changes relative to gestational age.
Machine learning models for predicting gestational age and time to delivery.

Main Results:

High analytical reproducibility (CV <20% for 93% of analytes).
Identification of 953 proteins modulated by gestational age, enriched in growth, angiogenesis, immunity, and inflammation pathways.
Machine learning prediction of gestational age and delivery time comparable to transcriptomic models.

Conclusions:

The plasma proteome provides a non-invasive readout of placental cellular dynamics throughout gestation.
Proteomic profiling during pregnancy can serve as a blueprint for investigating obstetrical diseases.
This approach holds promise for improved monitoring and prediction of pregnancy complications.