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Updated: Aug 27, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
Significant Role of Long Non-coding RNAs in Parkinson's Disease
Chen Na1, Chen Wen-Wen1, Wang Li1
1Department of Pharmacy, Institute of Advanced Pharmaceutical Technology, College of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China.
Background:
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, with clinical manifestations of resting tremor, akinesia (or bradykinesia), rigidity, and postural instability. However, the molecular pathogenesis of PD is still unclear, and its effective treatments are limited. Substantial evidence demonstrates that long non-coding RNAs (lncRNAs) have important functions in various human diseases, such as cancer, cardiovascular disease, and neurodegenerative diseases. Therefore, the main purpose of this study is to review the role of lncRNAs in the pathogenesis of PD.
Methods:
The role of lncRNAs in the pathogenesis of PD is summarized by reviewing Pubmed.
Results:
Thirty different lncRNAs are aberrantly expressed in PD and promote or inhibit PD by mediating ubiquitin-proteasome system, autophagy-lysosomal pathway, dopamine (DA) neuronal apoptosis, mitochondrial function, oxidative stress, and neuroinflammation.
Conclusion:
In this direction, lncRNA may contribute to the treatment of PD as a diagnostic and therapeutic target for PD.
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