Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

3.6K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
3.6K
Conjugated Proteins02:50

Conjugated Proteins

18.5K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.5K
Peptide Bonds02:43

Peptide Bonds

75.8K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
75.8K
Leaky Scanning02:28

Leaky Scanning

5.2K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.2K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

886
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
886

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut Hi-C metagenomes of severe COVID-19 patients: bacteria and yeast involved in gut-lung axis.

mSphere·2026
Same author

Lymphotoxin Beta Receptor, but Not Its Lymphotoxin Alpha-Containing Ligands, Is Essential for the Development of Experimental Dermatitis.

Biochemistry. Biokhimiia·2026
Same author

Bispecific Mini-Antibody with an Anti-CD14 Module Effectively Controls Bioavailability of the Human Tumor Necrosis Factor Produced by Human Monocytes.

Biochemistry. Biokhimiia·2026
Same author

Two-Stage Purification of Recombinant Antibodies Using Non-Ionic Detergent Prevents Endotoxin-Induced Macrophage Activation: The Case of Bispecific Mini-Antibody MYSTI-2.

Biochemistry. Biokhimiia·2026
Same author

Insertion in the N-Terminal Domain of the SARS-CoV-2 Spike Glycoprotein Affects Antibody Recognition and Phenotypic Properties.

Viruses·2026
Same author

Immunometabolic Properties of Tissue-Resident Alveolar Macrophages Depend on <i>ex vivo</i> Culturing Conditions.

Biochemistry. Biokhimiia·2026

Related Experiment Video

Updated: Aug 27, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.9K

Will Peptides Help to Stop COVID-19?

Viktoriya G Krut'1, Sergei A Chuvpilo1, Irina V Astrakhantseva1

  • 1Sirius University of Science and Technology, Federal Territory Sirius, Krasnodar Krai, 354340, Russia.

Biochemistry. Biokhimiia
|September 26, 2022
PubMed
Summary
This summary is machine-generated.

This review explores using peptides for COVID-19 prevention and treatment. Peptides show potential in blocking SARS-CoV-2 entry and developing vaccines against new variants.

Keywords:
ACE2SARS-CoV-2T-cell epitopesvaccine

More Related Videos

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
07:53

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

Published on: January 9, 2019

33.3K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K

Related Experiment Videos

Last Updated: Aug 27, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.9K
A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
07:53

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

Published on: January 9, 2019

33.3K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K

Area of Science:

  • Biotechnology
  • Virology
  • Immunology

Background:

  • Peptides are versatile tools in medicine, utilized in diagnostics, prevention, and therapy.
  • The emergence of SARS-CoV-2 (the virus causing COVID-19) necessitates novel therapeutic and preventative strategies.

Purpose of the Study:

  • To review the potential applications of synthetic and recombinant peptides in combating COVID-19.
  • To explore peptide-based strategies for blocking the SARS-CoV-2 and ACE2 receptor interaction.
  • To assess the role of peptides in developing vaccines, including those effective against emerging variants.

Main Methods:

  • Literature review of existing research on peptide applications in infectious diseases.
  • Analysis of studies investigating peptide interactions with SARS-CoV-2 and the ACE2 receptor.
  • Evaluation of peptide-based vaccine development strategies.

Main Results:

  • Peptides can be engineered to inhibit the binding of SARS-CoV-2 to the ACE2 receptor, potentially preventing viral entry.
  • Synthetic and recombinant peptides show promise as components of novel antiviral vaccines.
  • Peptide-based approaches may offer advantages in targeting new and emerging SARS-CoV-2 variants.

Conclusions:

  • Peptides represent a promising avenue for the development of COVID-19 prevention and therapeutic strategies.
  • Further research into peptide design and application is warranted for effective control of COVID-19 and future viral threats.