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Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces
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Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces.

Steven V Iasella1, Sourav Barman2, Clara Ciutara2

  • 1Department of Chemical Engineering and Materials Science, University of Minnesota; iasel001@umn.edu.

Journal of Visualized Experiments : Jove
|September 26, 2022
PubMed
Summary

This study introduces a capillary pressure microtensiometer (CPM) for precise interfacial characterization. The CPM enables rapid measurement of surfactant adsorption and dynamic surface tension with simultaneous fluorescence imaging.

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Area of Science:

  • Physical Chemistry
  • Surface Science
  • Materials Science

Background:

  • Adsorption of surface-active molecules at fluid-fluid interfaces is fundamental in natural and industrial processes.
  • Accurate characterization of interfacial properties, including surfactant adsorption rates and surface tension, is crucial.
  • Existing techniques have limitations in precision, response time, and simultaneous visualization.

Purpose of the Study:

  • To develop and validate a novel capillary pressure microtensiometer (CPM) for precise interfacial characterization.
  • To enable simultaneous measurement of dynamic surface tension and visualization of interfacial structure.
  • To enhance the speed and precision of surfactant adsorption and surface tension measurements.

Main Methods:

  • Utilized a capillary pressure microtensiometer (CPM) with a hemispherical air bubble pinned in a liquid reservoir.
  • Employed a microfluidic flow controller for precise control of capillary pressure, bubble curvature, or area based on the Laplace equation.
  • Integrated high-speed confocal fluorescence microscopy for simultaneous visualization and tracking of fluorescently tagged species.
  • Applied small pressure oscillations to determine the dilatational modulus.

Main Results:

  • Achieved enhanced measurement and control precision with millisecond response times, surpassing previous techniques.
  • Enabled accurate determination of dynamic surface tension and bubble curvature radius.
  • Demonstrated the capability to quantitatively track fluorescently tagged species with submicron lateral resolution.
  • Successfully measured the dilatational modulus through controlled bubble radius oscillations.

Conclusions:

  • The CPM offers a significant advancement for studying interfacial phenomena with unprecedented speed and precision.
  • The integrated approach allows for direct evaluation of structure-function relationships at interfaces.
  • This technique is valuable for fundamental research and applications involving surfactants and interfacial dynamics.