Related Experiment Video
Updated: Aug 27, 2025
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
13.9K
Chromoblastomycosis: A case series from Eastern China.
Sujun Liu1, Huilin Zhi1, Hong Shen1
1Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Plos Neglected Tropical Diseases
|September 26, 2022
Summary
Chromoblastomycosis (CBM) is a chronic fungal infection affecting skin and subcutaneous tissues. This study highlights CBM
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Chromoblastomycosis (CBM) is a chronic fungal infection of the skin and subcutaneous tissues.
- Caused by pigmented fungi, CBM is prevalent in China, with limited case series from Eastern China.
- Fonsecaea monophora is a common CBM pathogen in China.
Purpose of the Study:
- To describe the clinical characteristics of CBM in Eastern China.
- To analyze diagnostic challenges and treatment outcomes.
Main Methods:
- Retrospective analysis of 11 CBM cases diagnosed between 2018 and 2021.
- Clinical data collection, including lesion type, duration, and severity.
- Mycological examination (direct microscopy and ITS sequencing) for pathogen identification.
Main Results:
- 11 cases (9 male) with disease duration from 3 months to 20 years.
- Plaque-type lesions were most common; 7 mild and 3 severe forms observed.
- Direct microscopy was positive in all cases; 10 isolates of F. monophora and 1 Cladophialophora carrionii identified.
- 8 cases were initially misdiagnosed, underscoring diagnostic challenges.
Conclusions:
- CBM remains a significant dermatological challenge, particularly severe forms.
- Direct microscopic examination is an effective diagnostic tool for CBM.
- Promoting direct microscopy in rural hospitals can improve CBM diagnosis and management.
