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Updated: Aug 27, 2025

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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
538
[Dialogue between bioethics and evidence- based medicine, a narrative ethics perspective]
1Universidad de Oxford, Santiago, Chile.
Summary
Evidence-Based Medicine (EBM) integrates scientific evidence into clinical decisions, but critics argue it may overlook patient individuality and context, potentially causing bioethical conflicts. This review explores EBM
Area of Science:
- Bioethics
- Medical Philosophy
- Clinical Practice Guidelines
Background:
- Evidence-Based Medicine (EBM) is the current standard in Western medicine, emphasizing scientific evidence over intuition in clinical decision-making.
- While EBM offers documented benefits, it faces criticism for potential reductionism and neglecting patient-specific context and the physician-patient relationship.
- These limitations can precipitate bioethical conflicts within healthcare settings.
Purpose of the Study:
- To review the interplay between Evidence-Based Medicine and Bioethics.
- To identify and analyze ethical conflicts arising from EBM implementation.
- To examine these conflicts through the lens of Narrative Ethics, as proposed by Paul Ricoeur.
Main Methods:
- Literature review examining the relationship between EBM and Bioethics.
- Analysis of ethical conflicts through the framework of Narrative Ethics.
Main Results:
- EBM's emphasis on scientific evidence may conflict with the nuanced, individual aspects of patient care.
- Potential for reductionism in EBM can lead to overlooking crucial contextual and relational factors.
- Narrative Ethics offers a framework to address the ethical challenges posed by EBM's limitations.
Conclusions:
- The integration of EBM requires careful consideration of its ethical implications.
- Bioethical conflicts can arise from EBM's potential to de-emphasize individual patient narratives and contextual factors.
- Narrative Ethics provides a valuable perspective for navigating these complex ethical dilemmas in clinical practice.
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