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Related Experiment Video

Updated: Aug 27, 2025

Inducement and Evaluation of a Murine Model of Experimental Myopia
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A Review of Pathologic Myopia.

Nilesh Raval1, Joann J Kang, Yu Hyon Kim

  • 1Department of Ophthalmology and Visual Sciences (N.R., J.J.K., Y.H.K.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

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|September 26, 2022
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Summary

Pathologic myopia, a major cause of vision loss, involves excessive eye elongation and posterior segment degeneration. This review covers its classification, causes, complications, and management strategies for visual impairment.

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Area of Science:

  • Ophthalmology
  • Medical Science

Background:

  • Pathologic myopia is a primary global cause of vision impairment.
  • It disproportionately affects developed nations in East and Southeast Asia.
  • The condition is characterized by excessive axial elongation and posterior segment degeneration.

Purpose of the Study:

  • To provide a comprehensive review of pathologic myopia.
  • To elucidate the classification, pathophysiology, and complications.
  • To discuss current management approaches for this vision-threatening condition.

Main Methods:

  • Literature review of existing studies on pathologic myopia.
  • Analysis of pathophysiologic mechanisms and clinical presentations.
  • Synthesis of data on classification, complications, and treatment.

Main Results:

  • Pathologic myopia results from excessive axial elongation.
  • Degeneration of posterior segment structures leads to vision loss.
  • Complications significantly impair visual function.

Conclusions:

  • Understanding the pathophysiology is crucial for managing pathologic myopia.
  • Early detection and intervention can mitigate visual impairment.
  • Further research is needed to fully elucidate mechanisms and improve treatments.