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Sutureless Lyophilized Amniotic Membrane Grafting for Corneal Epithelial Defects
Maxime Delbarre1, William Boucenna, Françoise Froussart-Maille
1Ophthalmology Department (M.D., F.F.-M.), Percy Military Hospital, Clamart, France; and Ophthalmology Department (W.B.), Amiens University Hospital Center, Amiens, France.
Eye & Contact Lens
|September 26, 2022
Summary
Lyophilized amniotic membrane (AM) under a bandage contact lens (BCL) effectively treats persistent epithelial defects (PEDs), improving vision with no complications. This sutureless approach offers a safe and efficient solution for corneal healing.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Corneal Surgery
Background:
- Persistent epithelial defects (PEDs) are a challenging clinical condition that can lead to significant vision impairment.
- Current medical treatments for PEDs have variable success rates, necessitating alternative therapeutic strategies.
Purpose of the Study:
- To evaluate the safety, tolerability, and efficacy of using lyophilized amniotic membrane (AM) Visio-AMTRIX under a bandage contact lens (BCL) for treating PEDs.
- To assess the impact of this treatment on visual acuity and the rate of corneal healing.
Main Methods:
- A retrospective study included 11 patients with PEDs unresponsive to medical treatment.
- Lyophilized AM (Visio-AMTRIX) was applied under a BCL.
- Patients were followed for at least 3 months post-treatment.
Main Results:
- Complete resolution of PEDs was achieved in 8 of 11 eyes after a single AM graft; 3 eyes required a second graft.
- Corneal epithelial healing occurred in an average of 11 days post-grafting.
- Best-corrected visual acuity significantly improved post-treatment (P=0.036), and the AM resorbed within 2 weeks without complications or recurrence.
Conclusions:
- Sutureless lyophilized amniotic membrane applied under a bandage contact lens is an effective treatment for persistent epithelial defects.
- This therapeutic approach leads to significant visual improvement and demonstrates a favorable safety profile.
