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Updated: Aug 27, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Ruthenium(II)-Catalyzed (4+2) Annulative Difunctionalization of Non-conjugated Alkenyl Amides with Hydroxamic Acid
Chandan Kumar Giri1, Suman Dana1, Mahiuddin Baidya1
1Department of Chemistry, Indian Institute of Technology Madras, 600036, Chennai, India.
Abstract:
Ru(II)-catalyzed C-H bond activation strategy has been capitalized through a (4+2) annulative difunctionalization of non-conjugated alkenyl amides. Under mild conditions, a broad range of (hetero)aromatic amides embedded with NH-OMe unit as an internal oxidant produced high-value dihydroisoquinolinone scaffolds in good to excellent yields. This heteroannulation is also effective with acrylamides to dispense dihydro-2-pyridones and accommodates bioactive scaffolds such as tocopherol, estrone, and amino acids.
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