Related Experiment Video
Updated: Aug 27, 2025

05:51
A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat
Published on: June 29, 2021
1.4K
[Degenerative cervical myelopathy]
Ratko Yurac1, José Manuel Matamala2, Juan José Zamorano1
1Unidad de Columna, Departamento de Ortopedia y Traumatología, Clínica Alemana de Santiago, Santiago, Chile.
Summary
Degenerative cervical myelopathy (DCM) is a growing cause of adult spinal cord dysfunction. Early diagnosis and management by spine surgeons are crucial to prevent neurological decline.
Area of Science:
- Neurology
- Neurosurgery
- Geriatrics
Background:
- Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction in adults, with increasing prevalence due to population aging.
- Delayed or missed diagnosis of DCM frequently leads to secondary neurological complications and long-term disability.
- The condition typically manifests as progressive neurological deterioration, encompassing motor, sensory, and sphincter dysfunction.
Purpose of the Study:
- To enhance awareness of degenerative cervical myelopathy (DCM) and its rising incidence.
- To assist non-surgical healthcare professionals in the timely diagnosis and management of DCM.
- To provide guidance on the appropriate assessment and treatment strategies for DCM.
Main Methods:
- Review of current literature on the diagnosis, natural history, and management of DCM.
- Emphasis on the role of Magnetic Resonance Imaging (MRI) and electrophysiological studies in assessing spinal cord damage.
- Clinical guidelines for patient referral, non-operative management, and surgical intervention.
Main Results:
- DCM diagnosis is often delayed, contributing to preventable neurological morbidity.
- Non-operative management is suitable for mild DCM with close monitoring and patient education.
- Surgical decompression is indicated for moderate to severe DCM to prevent further progression.
Conclusions:
- Timely referral to a spine surgeon is essential for all patients with suspected DCM.
- Asymptomatic individuals with spinal cord compression require structured follow-up rather than immediate surgery.
- Effective management of DCM hinges on early recognition and appropriate, tailored treatment strategies.
Related Concept Videos
Myasthenia Gravis: Overview and Treatment
1.8K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.8K
Disorders of the Skeletal Muscle
1.0K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.0K
Cross-bridge Cycle
118.0K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
118.0K
Parkinson's Disease: Overview
672
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
672
Spinal Cord: Gross Anatomy
3.5K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
3.5K

