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Treatment of gastric carcinoma with lymphoid stroma by immunotherapy: A case report
Yu-Jie Cui1, Yan-Yan Ren2, Hong-Zhen Zhang3
1Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China.
Background:
Gastric cancer with lymphoid stroma (GCLS) is a rare type of gastric cancer characterized by abundant lymphocytic infiltration of the stroma. It is an Epstein-Barr virus-associated gastric cancer with a better prognosis than typical gastric cancer but with similar symptoms. GCLS diagnosis is based on pathological, histological and immunohistochemical examination and there are no standardized guidelines for treatment.
Case Summary:
This case report describes a 72-year-old man with a 6-mo history of abdominal pain. Endoscopy revealed ulcerative lesions in the stomach and gastric cancer was suspected. A preoperative endoscopic biopsy indicated undifferentiated carcinoma and postoperative pathological, histological and immunohistochemical analyses of the resected specimen confirmed a final diagnosis of GCLS.
Conclusion:
The patient showed high programmed cell death-ligand 1 expression and recovered well after immunotherapy.
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