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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
623
Metabolomics in Otorhinolaryngology
Antonio Noto1, Cristina Piras1, Luigi Atzori1
1Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Frontiers in Molecular Biosciences
|September 26, 2022
Summary
Metabolomics is revolutionizing Ear, Nose, and Throat (ENT) care by integrating "omics" sciences. This approach enhances diagnostics, prognostics, and therapeutics for diverse ENT conditions, paving the way for precision medicine.
Area of Science:
- Otorhinolaryngology (Ear, Nose, and Throat-ENT)
- Metabolomics
- Precision Medicine
Background:
- ENT disorders encompass inflammatory, immunological, infectious, and neoplastic conditions of the head and neck.
- Current ENT diagnostics include audiology, Vestibology, laryngology, phoniatrics, and rhinology.
- Metabolomics integrates genomics, transcriptomics, and proteomics, offering a comprehensive view of biological systems.
Purpose of the Study:
- To review the impact of metabolomics on Ear, Nose, and Throat (ENT) disorders.
- To highlight the potential and challenges of metabolomics in ENT diagnostics and treatment.
- To provide an understanding of metabolites associated with various ENT conditions.
Main Methods:
- Review of current literature on metabolomics applications in ENT.
- Focus on heterogeneous ENT diseases including head and neck cancer, allergic rhinitis, hearing loss, obstructive sleep apnea, sinusitis, and Meniere's disease.
- Analysis of how metabolomics can link diverse pathologies.
Main Results:
- Metabolomics offers a unifying approach ('fil rouge') across various ENT pathologies.
- The study identifies key metabolites relevant to specific ENT conditions.
- Metabolomics demonstrates potential to significantly alter ENT disorder diagnosis and treatment strategies.
Conclusions:
- Metabolomics is a powerful tool with the potential to transform ENT care.
- Application of metabolomics can improve diagnostics, prognostics, and therapeutics in ENT.
- Metabolomics is crucial for advancing precision medicine in the field of Otorhinolaryngology.
