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Related Experiment Video

Updated: Aug 27, 2025

Establishing a High Throughput Epidermal Spheroid Culture System to Model Keratinocyte Stem Cell Plasticity
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Hormesis and Epidermal Stem Cells.

Edward J Calabrese1, Vittorio Calabrese2

  • 1School of Public Health and Health Sciences, Environmental Health Sciences, University of Massachusetts, Amherst, MA, USA.

Dose-Response : a Publication of International Hormesis Society
|September 26, 2022
PubMed
Summary
This summary is machine-generated.

Hormetic dose responses in epidermal stem cells (EpSCs) enhance cell proliferation and differentiation. This approach shows promise for wound healing, aging, and preventing skin diseases.

Keywords:
biphasic dose responsecancer risk assessmentdose responseepidermal stem cellshormesisstem cells

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Area of Science:

  • Dermatology and Stem Cell Biology
  • Cellular Biology and Toxicology

Background:

  • Hormetic dose responses, a biphasic effect where low doses stimulate and high doses inhibit, are well-documented in various stem cells.
  • Research into hormesis in epidermal stem cells (EpSCs) is limited, with most exploration occurring in the last five years.

Purpose of the Study:

  • To assess hormetic dose responses in epidermal stem cells (EpSCs).
  • To explore the application of hormesis in wound healing, aging, and disease prevention.
  • To investigate the mechanisms and therapeutic potential of hormesis in EpSCs.

Main Methods:

  • Review of existing literature on hormetic dose responses in EpSCs in animal models and humans.
  • Analysis of agents inducing hormetic responses, including dietary supplements, pharmaceuticals, and endogenous factors.
  • Examination of effects on cell proliferation, differentiation, and inflammatory stress resilience.

Main Results:

  • Hormetic responses in EpSCs can be induced by various agents, influencing cell proliferation and differentiation.
  • Findings suggest hormesis can enhance EpSC functions and resilience to inflammatory stresses.
  • This study provides an integrated assessment of hormesis within EpSC biology.

Conclusions:

  • Hormesis represents a promising strategy for enhancing epidermal stem cell functions.
  • Therapeutic applications of hormesis in EpSCs may prevent dermatological injury and disease, and impact aging processes.
  • Further research into hormetic mechanisms in EpSCs is warranted for clinical translation.