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Related Experiment Video

Updated: Aug 27, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Leukoderma Induced by Rotigotine Patch, a Transdermal Dopamine Agonist.

Ronan Talty1,2, Goran Micevic1,2, Alice Wang1,3

  • 1Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.

Case Reports in Dermatology
|September 26, 2022
PubMed
Summary
This summary is machine-generated.

Leukoderma, a skin depigmentation, can be a side effect of rotigotine transdermal patches. This case report details a patient who developed this condition on the shoulders after using the patch for restless leg syndrome.

Keywords:
DopamineLeukodermaMelaninParkinson's diseaseRotigotineTyrosinase

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Leukoderma (hypomelanosis) can arise from various chemical and pharmacologic agents.
  • Rotigotine transdermal patches are used for conditions like restless leg syndrome (RLS).

Observation:

  • A 78-year-old man using rotigotine patches daily for 1 year developed leukoderma on his shoulders.
  • The depigmentation occurred in the specific areas where the patches were applied.

Findings:

  • Histopathology confirmed an absence of melanocytes at the dermal-epidermal junction.
  • Melan A staining verified the lack of melanocytes, indicating drug-induced hypopigmentation.

Implications:

  • This case highlights leukoderma as a potential adverse effect of dopamine transdermal patches.
  • It suggests a possible mechanism involving dopamine agonism leading to hypopigmentation.