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Trends in anti-HER2 drugs consumption and influencing factors

Jie Liu1, Xiaolei Zhang2, Biao Wang3

  • 1Department of Pharmacy, Nanjing Pukou Central Hospital, Pukou Branch of Jiangsu Province Hospital, Nanjing, China.

Frontiers in Public Health
|September 26, 2022
PubMed
Abstract

Insights

Anti-HER2 drug consumption in Nanjing significantly increased from 2017-2021 due to policy changes and new generics. This led to lower drug costs, but clinical benefit translation needs further attention.

Area of Science:

  • Oncology
  • Pharmacoeconomics
  • Health Policy

Background:

  • Human epidermal growth factor receptor 2 (HER2) inhibitors are crucial for treating HER2-amplified cancers.
  • Chinese government initiatives have focused on improving access and affordability of these vital medications.
  • Understanding consumption trends and influencing factors is essential for optimizing cancer care.

Purpose of the Study:

  • To analyze anti-HER2 drug consumption trends in Nanjing from 2012 to 2021.
  • To investigate the impact of national policies on anti-HER2 drug utilization and cost.
  • To identify key factors driving changes in drug consumption patterns.

Main Methods:

  • Utilized drug consumption data (defined daily doses [DDDs] and expenditure) from 2012-2021.
  • Employed time series analysis to identify consumption trends.
  • Applied interrupted time series analysis to assess policy impacts on drug use.

Main Results:

  • Anti-HER2 drug consumption and expenditure grew continuously from 2017-2021, with decreasing defined daily costs (DDCs).
  • Tyrosine kinase inhibitors surpassed monoclonal antibodies in DDDs by 2020-2021; pyrotinib usage exceeded trastuzumab.
  • National health insurance coverage, price negotiations, and generic/biosimilar availability significantly increased DDDs.

Conclusions:

  • Significant increases in anti-HER2 drug consumption and decreases in DDC observed post-2017 policy implementations.
  • Policy interventions and market changes positively impacted drug affordability and accessibility.
  • Translating increased consumption into tangible clinical benefits requires ongoing evaluation and effort.
Keywords:
anti-HER2 drugconsumptiongeneric drug replacementnational drug price negotiationnational health insurance coverage

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