Multiple Evanescent White Dot Syndrome Developing Three Days following Administration of mRNA-1273 Booster Vaccine:...

Area of Science:

• Ophthalmology
• Vaccinology
• Immunology

Background:

• The potential for ocular adverse events following mRNA-1273 vaccine (Moderna) administration remains largely uncharacterized.
• Investigating rare neurological and ocular side effects is crucial for vaccine safety surveillance.

Observation:

• A case report details a 71-year-old myopic female experiencing visual disturbances, including pulsating lights and scotoma, in her left eye.
• Symptoms began approximately three days post-Moderna mRNA-1273 vaccine booster.
• Ophthalmic examination revealed multiple, scattered white-yellow lesions in the outer retina of the affected eye.

Findings:

• The clinical presentation and funduscopic findings were consistent with a diagnosis of multiple evanescent white dot syndrome (MEWDS).
• The condition exhibited a short-lived and self-limiting course, with spontaneous improvement of visual symptoms and retinal lesions.
• No specific treatment was required, underscoring the benign nature of this particular ocular event.

Implications:

• Ophthalmologists should consider recent vaccination history, including mRNA-1273 boosters, when evaluating patients presenting with MEWDS.
• This case contributes to the understanding of potential, albeit rare, ocular side effects associated with mRNA vaccines.
• Further research may be warranted to explore any potential immunologic links between mRNA vaccination and inflammatory retinal conditions like MEWDS.