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Related Concept Videos

Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

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The complement system and autoimmune diseases.

Changhao Jia1,2, Ying Tan1, Minghui Zhao1,2,3

  • 1Laboratory of Renal Disease, Department of Medicine, Renal Division, Ministry of Health of China, Peking University First Hospital Peking University Institute of Nephrology Beijing China.

Chronic Diseases and Translational Medicine
|September 26, 2022
PubMed
Summary
This summary is machine-generated.

The complement system is crucial in autoimmune diseases, often affecting the kidneys. Understanding its abnormal activation reveals new therapeutic targets for conditions like lupus and vasculitis.

Keywords:
ANCA‐associated vasculitidesantiphospholipid syndromeautoimmune diseasecomplementsystemic lupus erythematosus

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Area of Science:

  • Immunology
  • Nephrology
  • Rheumatology

Background:

  • The complement system, a vital part of innate immunity, can paradoxically contribute to autoimmune disease pathogenesis.
  • Kidney injury is a common and serious complication in many autoimmune conditions.
  • Growing evidence links aberrant complement system activation to the onset and progression of autoimmune disorders.

Purpose of the Study:

  • To review recent research on the complement system's role in autoimmune disease pathogenesis.
  • To highlight specific autoimmune diseases where complement activation is implicated.
  • To identify potential therapeutic strategies targeting the complement system.

Main Methods:

  • Literature review of recent studies.
  • Analysis of complement system activation pathways in autoimmune diseases.
  • Synthesis of findings related to systemic lupus erythematosus, antiphospholipid syndrome, and antineutrophil cytoplasmic antibody-associated vasculitides.

Main Results:

  • The complement system's abnormal activation is a significant factor in the pathogenesis of various autoimmune diseases.
  • Specific examples include systemic lupus erythematosus, antiphospholipid syndrome, and ANCA-associated vasculitides.
  • Understanding these mechanisms provides insights into disease progression and potential treatment avenues.

Conclusions:

  • The complement system plays a critical role in the development and progression of autoimmune diseases, often leading to kidney damage.
  • Targeting complement system activation presents a promising strategy for novel therapeutic interventions.
  • Further research into complement pathways can uncover new treatment targets for autoimmune conditions.