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Fat Grafting as Regenerative Surgery: A Current Review
Joseph M Firriolo1, Alexandra Condé-Green1, Lee L Q Pu1
1From the Division of Plastic Surgery, University of California Davis Medical Center; and private practice, Delray Beach.Received for publication May 22, 2021; accepted February 3, 2022.
Plastic and Reconstructive Surgery
|September 26, 2022
Summary
Autologous fat grafting offers regenerative potential beyond its filler capabilities, addressing conditions like scarring and autoimmune diseases. Further research is needed to establish evidence-based protocols for this emerging field of regenerative surgery.
Area of Science:
- Regenerative Medicine
- Plastic Surgery
- Tissue Engineering
Background:
- Autologous fat grafting is recognized for soft-tissue contour restoration.
- Recent findings highlight its regenerative capacity due to adipose-derived stem cells.
- This has spurred the development of regenerative surgery.
Approach:
- Investigating the regenerative mechanisms of fat grafting.
- Exploring its therapeutic potential in various clinical conditions.
- Evaluating its angiogenic and immunomodulatory properties.
Key Points:
- Fat grafting demonstrates regenerative potential for scarring, fibrosis, atrophy, burns, neuropathic pain, and autoimmune diseases.
- It offers functional and aesthetic improvements, enhancing quality of life.
- The procedure may provide a less invasive alternative to conventional surgical techniques.
Conclusions:
- Regenerative fat grafting shows promise for complex clinical issues.
- Its angiogenic and immunomodulatory effects are significant, particularly in autoimmune diseases.
- Further research is essential to define evidence-based protocols and elucidate precise regenerative mechanisms.
