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Paradoxical roles for programmed cell death signaling during viral infection of the central nervous system

Juan P Angel1, Brian P Daniels2

  • 1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA. Electronic address: https://twitter.com/JuanP_Angell.

Current Opinion in Neurobiology
|September 26, 2022
PubMed

Insights

Programmed cell death (PCD) is vital for fighting infections. New research shows diverse PCD signaling in the central nervous system (CNS) during infection, with complex outcomes for disease control and therapy.

Area of Science:

  • Immunology
  • Neuroscience
  • Cellular Biology

Background:

  • Programmed cell death (PCD) is a critical immune defense against pathogens.
  • Infection triggers diverse PCD types, influencing immune responses.
  • The central nervous system (CNS) presents unique challenges for studying PCD during infection.

Purpose of the Study:

  • To review recent findings on PCD signaling in the infected CNS.
  • To highlight the complexity and dual roles of PCD in CNS infections.
  • To identify future directions for understanding neuroinvasive infections and developing therapies.

Main Methods:

  • Literature review of recent studies on PCD in the CNS.
  • Analysis of molecular mechanisms regulating PCD in neuroinflammation.
  • Synthesis of data on protective and pathological PCD outcomes.

Main Results:

  • PCD signaling in the CNS is highly complex during infection.
  • CNS cells exhibit unique regulation of PCD pathways.
  • PCD can have both beneficial and detrimental effects on infection control in the CNS.

Conclusions:

  • Understanding CNS-specific PCD mechanisms is crucial for neuroinvasive infections.
  • PCD signaling complexity in the CNS offers therapeutic targets.
  • Further research into molecular mechanisms will advance treatment strategies.

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