CohesinDB: a comprehensive database for decoding cohesin-related epigenomes, 3D genomes and transcriptomes in human...

Area of Science:

• Molecular Biology
• Genomics
• Epigenetics

Background:

• Cohesin plays a crucial role in gene regulation and chromatin structure.
• Cohesin's function is context-dependent, varying with epigenetic properties of chromatin loci.
• Integrating large-scale cohesin datasets from next-generation sequencing is challenging.

Purpose of the Study:

• To develop CohesinDB, a comprehensive multiomics database for cohesin in human cells.
• To integrate diverse datasets for a unified view of cohesin binding sites, chromatin loops, and cis-regulatory modules (CRMs).
• To provide a user-friendly platform for accessing and analyzing cohesin-related information.

Main Methods:

• Data integration from 2043 epigenomics, transcriptomics, and 3D genomics datasets.
• Inclusion of data from 530 studies across 176 human cell types.
• Development of a database summarizing cohesin binding sites, chromatin loops, and CRMs.

Main Results:

• CohesinDB contains over 2.2 million cohesin-related objects, including binding sites, loops, and CRMs.
• Each object is annotated with detailed information on locus, cell type, function, and 3D genomics.
• The database offers functionalities for browsing, searching, analysis, visualization, and data download.

Conclusions:

• CohesinDB serves as a valuable, integrated resource for researchers in cohesin biology, epigenomics, and transcriptional regulation.
• The database facilitates exploration of cohesin's multifaceted roles in chromatin organization and gene expression.
• CohesinDB promotes further research by simplifying access to complex cohesin-related data.