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Safety of routine childhood vaccine coadministration versus separate vaccination

Jorgen Bauwens1,2, Simon de Lusignan3,4, Yonas Ghebremichael Weldesselassie5

  • 1University of Basel Children's Hospital, Basel, Switzerland bauwens.jorgen@gmail.com.

BMJ Global Health
|September 26, 2022
PubMed

Insights

Coadministering routine childhood vaccines is generally safe, with most adverse events following immunization (AEFI) showing no significant difference compared to separate vaccinations. Some specific vaccine combinations showed increased risks for certain AEFI, warranting further investigation into severity.

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • Vaccine coadministration is increasingly used to improve delivery efficiency for healthcare systems and patients.
  • Understanding the safety profile of coadministered vaccines compared to separate administration is crucial for public health policy.

Purpose of the Study:

  • To compare the safety of 20 vaccine coadministrations with separate vaccinations.
  • To identify specific adverse events following immunization (AEFI) associated with coadministration.

Main Methods:

  • An observational cohort study using real-world immunisation and AEFI data from 2008-2018.
  • Self-controlled case series method applied to calculate relative incidence ratios (RIR) for AEFI.

Main Results:

  • No significant difference in AEFI for 72% of coadministrations; 17% occurred less frequently, and 11% more frequently.
  • Amplifying interaction effects observed for specific AEFI with certain multi-vaccine coadministrations (e.g., fever, rash, gastrointestinal, respiratory events).
  • No indication that unscheduled coadministrations are less safe than scheduled ones.

Conclusions:

  • Real-world data support the coadministration of routine childhood vaccines as per the immunisation schedule.
  • Further research is needed to fully understand the severity and burden of AEFI following vaccine coadministration.
Abstract

Keywords:
immunisationprevention strategiespublic healthvaccines

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